Marine macrolide antiviral activity

Table 12 illustrates the reported antiviral activities of the common marine secondary metabolites polyacetylenes, quinones/pyrones, macrolides and prostaglandins. 

Balticolide 60 (Scheme 6.12), a new 12-membered macrohde, was isolated by Shushni et al. [76] from the marine fungus belonging to the ascomycetous species. It exhibited antiviral activity (anti-HSV) with an ICjq value of 0.45 aM. Structurally 60 is attractive because of its differently positioned functional groups in comparison with the related macrolides. Radha Krishna et al. [77] reported the synthesis of 60 by RCM on fois-olefin 57, which resulted in the natural product along with its Z-isomer Z-60. 

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