Mapping Chemical Space by Self-organizing Maps A Pharmacophore Road Map

Mapping Chemical Space by Self-organizing Maps A Pharmacophore Road Map 

A list of privileged scaffolds - several of which are natural-product derived - for target-family-biased combinatorial libraries was recently presented by Muller [94], These scaffolds were proven to produce biologically active compounds for more than one member of a given target family. A rough-and-ready in-silico evaluation 

Although this method has not yet been applied to library design, it represents a promising approach that might help improve the SOM-based pharmacophore road map. 

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