Mannose-binding pocket

Fig. 6 Crystal structure of FimC FimH chaperone adhesin complex bound to a-D-mannose [57], showing the chaperone FimC (yellow Gd strand red), the pi I in domain of FimH (steel-blue) that is donor-strand complemented by the chaperone Gd strand, and the receptor-binding domain (violet with blue-green helices, secondary structure labelled as described earlier [32]). D-Mannose bound to the mannose-binding pocket is shown as a ball-and-stick model...

Fig. 10 Fructose superimposed on mannose in the FimH binding pocket. Fructose in green (for clarity of the picture, each atom was shifted 0.3 A from the ideal superposition), mannose in grey. The two different Tyr48 side chain conformations are shown. Note the lack of 01 of mannose (anomeric oxygen) and the presence of (an extra) hydroxyl on C2 (the equivalent of C5 of mannose) that is in close contact (2.7 A) with Ile52 (orange dashed bond)...

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