Mannitol radiocontrast agents

Solomon R, Werner C, Mann D, O Elia J, Silva R Effects of saline, mannitol, and furosemide to prevent acute decreases in renal function induced by radiocontrast agents, N Engl J Med 1994 331 1416-1420. 

Most investigators administer 0.45% saUne in combination with 5% dextrose intravenously in various amounts (around 1000-1500 ml starting 12 hours before administration of radiocontrast agents). There is no controlled study that assessed oral hydration in these patients. Until now, there has been no investigation as to how long hydration should be continued. From a theoretical point of view the use of hyperosmolar fluids (such as 15% mannitol) in addition to the administration of the hyperosmolar contrast media may have adverse effects. Therefore, it is not surprising that most studies failed to observe a benefi-... 

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