Mannitol 1.6- dibromo-1,6-dideoxy

Tharapautic Function Cancer chemotherapy Chemical Name 1,6-dibromo-1,6-dideoxy-D-mannitol Common Name —... 

Intramolecular cyclization can also be effected with acyclic intermediates derived from such readily available alditols as D-mannitol. Kuszmann and Vargha63 reported the formation of 2,5-anhydro-l,6-dibromo-l,6-dideoxy-4-0-(methylsulfonyl)-D-glucitol (63), in 73% yield, by boiling 3,5-di-0-acetyl-l,6-dibromo-l,6-dideoxy-2,4-di-0-... 

More recently a group of halogenated sugars have been found to have similar properties to the bifunctional alkylating agents 1. 1,6-Dibromo- 1,6-dideoxy-D-mannitol, for example (DBD, Mitobronitol 10) is now in clinical use, but it is believed to act at least in part by transformation in vivo to the bis epoxide... 

A standard sequence of conversions has been used to convert 1,6-dibromo-1,6-dideoxy-3,4-0-isopropylidene-D-mannitol by chain elongation to the 3,6-diamino-l,4 5,8-dianhydro-L-manno- and L-ido-22... 

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