Mannich Reactions with Cinchona-derived PTC Catalysts

6 Mannich Reactions with Cinchona-derived PTC Catalysts 

Nucleophilic addition to the C=N bond of imine derivatives is quite important in organic chemistry for the synthesis of functionalised amines and related nitrogen-containing compounds. This section introduces an enan-tioselective Mannich reaction, including an aza-Henry reaction that uses nitroalkanes as a nucleophile, via PTC catalysis in the presence of Cinchona-derived quaternary ammonium salts. 

---