Mannich reactions lithium chloride

In addition, the lithium enolate derived from pseudoephedrine propionamide has been shown to undergo highly diastereoselective Mannich reactions with p-(methoxy)phenyl aldimines to form enantiomerically enriched a,p-disubstituted p-amino acids (Table 10). As observed in alkylation reactions using alkyl halides as electrophiles, lithium chloride is necessary for the reaction of aldimines. With respect to the enolate, the stereochemistry of the alkylation reactions is the same as that observed with... [Pg.492]

Synthetic strategy Mukaiyama-type Mannich reaction Catalyst Lithium chloride (LiCl)... [Pg.31]

Keywords Arylaldemines, trimethylsilyl ketene acetal, lithium chloride, DMF, room temperature, Mukaiyama-type Mannich reaction, p-amino esters... [Pg.31]

Hagiwara, H., lijima, D., Awen, B. Z. S., Hoshi, T., and Suzuki, T. (2008). Expedient Mukaiyama-type Mannich reaction catalyzed by lithium chloride. Synlett, 1520-1522. [Pg.31]

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