Mannich reaction bimolecular aromatic

The chemistry that has been reviewed in this chapter demonstrates that although the bimolecular Mannich reactions of aromatic compounds have now reached the venerable stage, they are still much used by synthetic organic chemists and that they are capable of further development. 

H. Heaney, The Bimolecular Aromatic Mannich Reaction, in Comprehensive Organic Synthesis (B. M. Trost, I. Fleming, Eds.), Vol. 2, 953, Peigamon Press, Oxford, 1991. 

The synthesis of the non-symmetric ligands is based on the Bimolecular Aromatic Mannich reaction. Non-symmetric ligands can be obtained via two different routes. The first route comprises a sequential Mannich reaction on a phenol using two different secondary amines. An alternative route is a Mannich reaction using a secondary amine and a substituted salicylaldehyde followed by either condensation of the aldehyde functionality with a primary amine and subsequent reduction or reductive amination with a secondary amine. 

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