Maleimidyl acetate

The Gabriel-Colman rearrangement entails reaction of the enolate of a maleimidyl acetate (2) to provide isoquinoline 1,4-diol 3. ... 

Reaction of the enolate of a maleimidyl acetate to provide isoquinoline 1,4-diol. 

A soln. of N-benzhydryldichloromaleimide in glacial acetic acid treated with a soln. of excess isoquinoline in glacial acetic acid at 100-110° for 1 hr. 2-(N-benzhydryl-2-oxy-3-maleimidyl)isoquinolinium betaine. Y 94%. F. e., also with equimolar amounts in the presence of triethylamine, which does not react under the above conditions, s. M. J. Karten et al., J. Org. Ghem. 30, 2657 (1965). 

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See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

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