Malaria Plasmodium structural biolog

Avery MA, McLean G, Edwards G, Ager A. Structure-activity relationships of peroxide-based artemisinin antimalarials. In Biologically Active Natural Products Pharmaceuticals. Cutler SI, Cutler HG, eds. 2000. CRC Press, Boca Raton, EL, pp. 121-132. Pareek A, Nandy A, Kochar D, Patel KH, Mishra SK, Mathur PC. Efficacy and safety of f -arteether and a/f -arteether for treatment of acute Plasmodium falciparum malaria. Am. J. Trop. Med. 2006 75 139-142. http //mednet3.who.int/EMUb/. 

Guaianohdes have also been intensively examined toward protozoa like members of the genera Trypanosoma (sleeping sickness), Leishmania (leishmaniasis), and Plasmodium (malaria) only studies that also tested cytotoxic activity are considered here. In all cases, an antiprotozoal activity correlates positively with cytotoxicity, and the major determinants for activity are a,p-unsaturated carbonyl residues. Certain compounds are considerably more toxic against protozoa than against mammalian cells and vice versa. A comparative QSAR analysis has been undertaken, and both activities were found to depend mainly on the same structural elements and molecular properties. The observed variance in the biological data can maybe be explained by the positioning of the various molecules in the active site [63-65]. 

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