Magnosalin

It was demonstrated that the use of phenyl vinyl sulfoxide or sulfone in a thermal Diels-Alder reaction was highly unsatisfactory as an alternate route. The synthesis of the neolignins galbulin, isogalbulin [82], magnoshinin, and magnosalin [83] have all been accomplished by means of a cation radical cycloaddition (Scheme 42). 

Scheme 42. Cation radical cycloadditions in the synthesis of magnosalin and magnoshinin.

Kakkonka senkyu shtn i Magnolia magnosalin, magnoshinin Anti-angiogenic effect ... 

Fig. (8). Inhibitory eflect of magnoshinin and magnosalin, neolignanes derived from "shin-i" (Flos Magnoliae) on proliferation of subcultured rat aortic endothelial cells (ECs) stimulated with 5% fetal bovine serum (FBS). Subconfluent ECs (cultured for 6 days) were synchronized by serum starvation for 2 days, and stimulated with 5% FBS and [ H]>thymidine in the presence and absence of the above compounds (0.1, 0.3, I or 3 pg/mL). Tritium thymidine incorporation was measured at 3-hr intervals in culture. The values represent means S.E.M. (n = 3-9).

Apoptosis/Angiogenesis. Induction of mitochondrial- and caspase-dependent apoptosis in mast cells and antiangiogenic activity (magnosalin) in rat vascular endothelial cells. ... 

SCHEME 10 J2 Biomimetic synthesis of magnosalin via photoinduced electron transfer. 

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