Magnesium dioxide: reaction with

The Grignard reagents prepared from the activated magnesium appear to react normally with electrophiles. Thus reactions with proton donors, ketones, and carbon dioxide afford hydrocarbons, alcohols, and carboxylic acids, respectively. The reductive coupling of ketones to pinacols had also been accomplished with the activated magnesium. ... 

S. Akutagawa and S. Otsuka, J. Amer. Chem. Soc., 1976, 98, 7420 the formula for isogeraniol lacks the 6,7-double bond and the diene minor product is named incorrectly. No experimental details are given for the hydrolysis of this myrcene-magnesium complex but the results contradict those reported by Cookson et al. who have extensively investigated its reactions with carbonyl compounds, epoxides, carbon dioxide, and acetonitrile. ... 

The magnesium bromide salt of indole gives the 3-carboxy derivatives in about 30% yield on reaction with carbon dioxide (56JCS2853). Ethyl indole-3-carboxylate can be obtained directly, but in modest yield, using ethyl chloroformate (62JOC496, 6602805). Indole-2-carboxylic acid derivatives can be obtained via the benzenesulfonyl-protected 2-lithio derivative (equation 181) (73JOC3324). 

SCHORIG1N (or Shorygin) REACTION. Organometallic reactions of the Grignard type, employing sodium in place of magnesium the reaction of alkyl sodium compounds with carbon dioxide to give monobasic acids is sometimes known as the Wanklyn reaction. 

The transformation of the saturated compounds into 1,2-oxathiolanes may be achieved under basic conditions. For example, cis- and frans-2,4-diphenylthietane 1,1-dioxides react with magnesium f-butoxide in refluxing ether to give a stereospecific ring expansion into cis- and trans-3,5-diphenyl- 1,2-oxathiolane 2-oxide, respectively. The reaction for the cis compound is shown in equation (42) the mechanism is unknown (B-73MI43000). 

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