Macromolecular antigens

Key amino acids in the hypervariable loops of Ab-2 are found by homology matching with sequences in the original macromolecular antigen (Williams et al., 1988). 

Some configurations used in non-competitive immunoassays include the following two. First, two-site (sandwich type) immunoassays, used for the determination of macromolecular antigens, where simultaneous binding of two antibodies to the... 

Macromolecular antigens, mostly proteins and glycoproteins, usually express in their structure a multitude of possible antigenic determinants, or epitopes, that... 

Chemical similarities can quite easily explain the observation of cross-allergies. Small conformational differences are enough indeed to create common epitopes (etymologically, superficial place ). An epitope is a part of molecule with a specific three-dimensional structure. One more time, we can see the importance of molecular structures in biology. Epitope is also called antigenic determinant. It can be incorporated in a macromolecular antigen by a group of specific amino acids, often exposed on the surface of the molecule (Fig. 3.27). ... 

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