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Macrocyclization using enyne metathesis

M. Shair and co-workers were the first to apply the enyne metathesis for macrocyclization during the biomimetic synthesis of (-)-longithorone A." The two 16-membered paracyclophane building blocks, one diene and one dienophile component, were prepared using 50 mol% Grubbs s first-generation catalyst under 1 atm ethylene gas pressure. These components, after several additional steps, underwent two facile Diels-Alder cycloaddition reactions to afford the natural product. [Pg.153]


See other pages where Macrocyclization using enyne metathesis is mentioned: [Pg.270]    [Pg.352]    [Pg.143]    [Pg.205]    [Pg.408]    [Pg.476]    [Pg.483]    [Pg.709]    [Pg.433]    [Pg.202]    [Pg.307]    [Pg.239]    [Pg.478]   
See also in sourсe #XX -- [ Pg.471 ]




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