Macrocyclic diaryl ether heptanoids

Fourteen new macrocyclic diaryl ether heptanoids have been described (Table 4). The total syntheses of compounds 88, 89, 90, 91, 94 and 101 have also been reported (cf. Table 4). Based on synthetic and spectroscopic evidence, the structure of garuganin III has been revised to 101 [46]. 

Type I non-phenolic linear diarylheptanoids Type II phenolic linear diarylheptanoids Type III macrocyclic biarylheptanoids Type IV macrocyclic diaryl ether heptanoids Type V diarylheptanoids with cyclised C7-chain. 

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