MAC-Awake

MAC awake is the concentration where responses to verbal commands are lost, this is also usually the point of amnesia and loss of awareness. 

Another term, the MAC-Awake, is used to describe the concentration of anesthetic at which appropriate responses to verbal commands are lost in 50% of the patients tested. At this concentration, amnesia and a loss of awareness are evident, and the patient is said to be in a state of hypnosis. The MAC-Awake occurs at concentrations significantly lower (e.g., 50-75% lower) than those required for surgical anesthesia. 

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