Lyzozyme

Fig. 2.17. Modified scheme of lyzozyme reaction. Nuclei participating in the formation of the transition state are marked by. (Vocadlo et al., 2001) Reproduced with permission.

Faber, H.R. and Mathews, B.W. (1990) A mutant T4 lyzozyme displays five different crystal conformations of hinge-like motion Nature 348, 263-. 

Nishimoto, E., Yamashita, S., Szabo, A. G., and Imoto, T. (1998) Internal motion of lyzozyme studied by time-resolved fluorescence depolarization of tryptophan residues, Biochemistry 37, 5599-5607. 

Lyzozyme, ovalbumin, and ovotransferrin from chicken egg white [13]... 

Kozack et al. found from Brownian dynamics simulations that the rates f association of lyzozyme with the Hy-HEL-5 antibody are sensitive to mutation of charged residues near the binding site and changes in ionic strength. For these studies, the motion of lysozyme was simulated under the influence of the electrostatic potential derived from a full-atom model of the antibody. Lyzozyme itself was modeled either by a positively charged sphere representing two Arg residues or by an asymmetric dumbbell the smaller sphere of which represented the two Arg residues. 

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