Lytic response

The multiplication of NK cells observed of up to 500-fold in certain cases is unprecedented. Furthermore, the bioactivity of the NK cells generated in the presence of dendrimers is not modified. Cultures with these dendrimers neither induced activation or inhibition of the NK cells lytic response, nor compromised direct toxicity for their target cells and preserved autologous lymphocytes. In view of this unprecedented result, several variations of the initial structure... 

When a temperate phage is mixed with sensitive indicator bacteria and plated as described above, the reaction at each focus of infection is generally a combination of lytic and lysogenic responses. Some bacteria will be lysed and produce phage, others will survive as lysogenic cells, and the plaque becomes visible as a partial area of clearing in the bacterial lawn. It is possible to pick off cells from the central areas of these plaques and demonstrate that they carry prophage. 

An antibiotic inhibition zone often appears around Trichoderma spp. interacting with other fungi. The genus contains many species which produce secondary metabolites. Claydon et al. (23) have identified an antibiotic from T. harzianum as a volatile, 6-n-pentyl-2H-pyran-2-one this was recently shown to be an active antibiotic from T. koningii (24). The volatile appeared to be the factor responsible for the coconut smell of some biocontrol-effective strains of T. harzianum (25). However, in a Petri-plate assay, it can be difficult to be certain that antibiosis is involved. As well as competitive growth, lytic enzymes could also contribute to the action and Trichoderma has been shown to produce / -l,3-glucanase and chitinase (26-29). 

Chlorpromazine s (CPZ) efficacy was discovered primarily by chance in exploratory clinical trials after it had been initially synthesized as an antihistamine. Its discovery, however, was not entirely fortuitous, because it was chosen for human investigation since it was mildly sedating. The concept of an antipsychotic, however, was unknown. CPZ s sedative properties then led the French anesthesiologist and surgeon Henri Laborit to use it in a lytic cocktail to reduce autonomic response with surgical stress (1). He also persuaded many clinicians to try it for the treatment of a wide variety of other disorders. In this context, he encouraged John Delay and Pierre Deniker (1952), who then administered CPZ to schizophrenic patients. The rest is history ( 2, 3). 

Fig. 71 In contrast to building 5a (see Fig. 68), the disinfestation wing of building 5b was used as a hydrogen cyanide delousing chamber for a longer period of time. Subsequently, the outside of its walls are covered with blue spots, unimpressed by 50 years of weathering here as well. lytical procedure may be responsible for (see footnote in Table 20).

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