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Lysosomes poly nanoparticles

Panyam J, Zhou WZ, Prabha S et al (2002) Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles implications for drug and gene delivery. FASEB J 16 1217-1226... [Pg.63]

Fig. 10.17 Cytoplasmic drug delivery using lysosomal-pH-responsive fast-release nanoparticles a the nanoparticle is internalized by endocytosis b transferred to a lysosome c the PDEA core is protonated at the lysosomal pH (4-5) and the nanoparticle dissolves, releasing the drug into the lysosome d the continuous PDEA (poly[2-(JV,A-diethylamino)ethyl methacrylate]) protonation causes an osmotic imbalance across the lysosome membrane, which finally ruptures the lysosome and hence releases the drug into cytoplasm... Fig. 10.17 Cytoplasmic drug delivery using lysosomal-pH-responsive fast-release nanoparticles a the nanoparticle is internalized by endocytosis b transferred to a lysosome c the PDEA core is protonated at the lysosomal pH (4-5) and the nanoparticle dissolves, releasing the drug into the lysosome d the continuous PDEA (poly[2-(JV,A-diethylamino)ethyl methacrylate]) protonation causes an osmotic imbalance across the lysosome membrane, which finally ruptures the lysosome and hence releases the drug into cytoplasm...
See other pages where Lysosomes poly nanoparticles is mentioned: [Pg.111]    [Pg.546]    [Pg.547]    [Pg.261]    [Pg.1190]    [Pg.336]    [Pg.291]    [Pg.240]    [Pg.163]    [Pg.363]    [Pg.6]    [Pg.194]    [Pg.460]    [Pg.466]    [Pg.42]    [Pg.56]    [Pg.312]    [Pg.21]   
See also in sourсe #XX -- [ Pg.138 ]



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