Lysosomal exoglycosidases

There are two lysosomal exoglycosidases that cleave HA termini from the non-reducing termini, one saccharide at a time, P-... 

Glycosphingolipids are catabolized by the stepwise hydrolysis of the terminal monosaccharides through the concerted action of a series of specific exoglycosidases (Fig. 10) [12]. There is often a requirement for SAPs, SAP-A, -B, -C, or -D, and GM2-activator protein, which is required for GM2 hydrolysis but can also accommodate other glycosphingolipids. Acidic lipids, and in particular BMP, are additionally involved in vivo as stimulators of glycosidase activity and are components of the lysosomal perimeter membrane. 

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