Lysine degradation

Valine, leucine, and isoleucine biosynthesis Lysine biosynthesis Lysine degradation Arginine and proline metabolism Histidine metabolism Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism Phenylalanine, tyrosine, and tryptophan biosynthesis Urea cycle and metabolism of amino groups... 

In mammals a single PPTase is used for the posttranslational modification of three different apo-proteins the carrier proteins of mitochondrial and cytosolic FASs and the aminoadipate semialdehyde reductase implicated in lysine degradation. The crystal structure of human PPT ase has been determined and found to be most closely related to the class II Sfp-like enzymes. Architectural and mechanistic differences between the type II human PPTase and the type I bacterial PPTases include a divalent cation coordinated by the a-phosphate of CoA, a Glu and an Asp residue, and three water ligands in type I PPTases versus a divalent cation coordinated by a- and /3-phosphates of CoA, two to three protein side chains, and a water molecule in the human PPT ase. 

Mg 2 were required for the reaction to proceed. The acetyl phosphate is utilized for the synthesis of acetyl-CoA, required for lysine degradation. The importance of Stadtman s finding becomes apparent upon close examination of the experimental data. 

Hyperlysinemia and hypersaccharopinuria 1 300,000 Lysine First two lysine degradation enzymes... 

C9. Colombo, J. P., Biirgi, W., Richterich, R., and Rossi, E., Congenital lysine intolerance with periodic aminoacid intoxication a defect in L-lysine degradation. Metab. Clin. Exp. 16, 910-925 (1967). 

Lysine degradation proceeds by several routes in various organisms, but, in general, the individual reactions have not been isolated. Isotopic studies in vivo with plants, animals, and Neurospora show conversion of lysine to pipecolic acid (VI). Since the a-amino nitrogen is lost in this... 

Kito M, Takimoto R, Yoshida T, Nagasawa T (2002a), Purification and characterization of an e-poly-L-lysine-degrading enzyme from an e-poly-L-lysine-producing strain of Streptomyces albulus . Arch Microbiol, 178, 325-330. 

Kito M, Onjii Y, Yoshida T, Nagasawa T (2002b), Occurrence of e-poly-L-lysine-degrading enzyme in e-poly-L-lysine-tolerant sphingobacterium multivorum OJIO purification and characterization , FEMS Microbiol Lett, 207, 147-151. 

Bremer, H. J., Wadman, S.K., Przyrembel, H., Wendel, U. and Lombeck, I. (1976), a-Ketoadipic aciduria - a new inborn defect of lysine degradation. Proceedings of the 12th Meeting of the Society for the Study of Inborn Errors of Metabolism, Heidelberg, 1974. In Inborn Errors of Calcium and Bone Metabolism (eds. H. Bickel and J. Stern), Medical and Technical Publishing Co., Lancaster, pp. 271-285. 

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