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Lysergic Acid Piperidide

A solution of 10 g of iso-lysergic acid azide in 50 cc. of tetrahydro-furan is mixed with 2 cc of piperidine, the mixture is warmed for two hours to 50°, the solvent is evaporated and a solution of the residue in ethyl acetate is extracted with aqueous sodium bicarbonate solution. The residue resulting from the evaporation of the dried ethyl acetate solution (11 g). Source Sandoz 1956 [Pg.58]

The process consists of reacting an optically active lysergic acid derivative of the formula  [Pg.59]

Examples of acids which may be used are inorganic acids, such as hydrochloric, hydrobromic or sulfuric acid, alkyl- or arylsulfonic acids, for example methanesulfonic or benzenesulfonic acid aliphatic and aromatic carboxylic acids such as formic, acetic or benzoic acid. [Pg.59]

The acid may be added to the reaction mixture as such or, simpler, by using a preformed acid addition salt of the alkaloid or of part of the hydrazine. [Pg.59]

The use of a solvent is as a rule unnecessary, as the excess hydrazine suffices to bring all reactants into solution. Nevertheless an additional solvent, such as a lower alcohol or a glycol, may be useful in certain cases. [Pg.59]


Fractional Crystallization of cZ-Lysergic Acid Piperidide cZ-Tartrate by Sandoz... [Pg.80]

On mixing equivalent amounts of lysergic acid piperidide and d-tartaric acid in 5 times the amount of methanol the (f-tartrate crystallizes in the form of needles having a melting point of 145-150° [a]D20=-t-15° (0.4% concentration in water). Source Sandoz 1956... [Pg.80]


See other pages where Lysergic Acid Piperidide is mentioned: [Pg.58]    [Pg.94]    [Pg.94]    [Pg.58]    [Pg.94]    [Pg.94]   


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Piperidides

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