Lupus erythematodes

Hydralazine and dihydralazine are predominantly arterial vasodilators which cause a reduction in peripheral vascular resistance but also reflex tachycardia and fluid retention. They were used in the treatment of hypertension, in combination with a -blocker and a diuretic. Long-term use of these compounds may cause a condition resembling lupus erythematodes with arthrosis, dermatitis and LE-cells in the blood. This risk is enhanced in women and in patients with a slow acetylator pattern. When combined with the venous vasodilator isosorbide (an organic nitrate) hydralazine was shown to be mildly beneficial in patients with congestive heart failure (V-HEFT I Study). Hydralazine and dihydralazine have been replaced by other therapeutics, both in hypertension treatment and in the management of heart failure. 

Moreover, MRL Mpf lpr/lpr (MRL/lpr)-mice were described which spontaneously develop a severe disease with many symptoms very similar to human systemic lupus erythematodes, i.e. hypergammaglobulinemia, and glomerulonephritis (Theofilopoulos and Dixon 1981). 

Korholz D, Nurnberger W, Gbbel U, Wahn V. Gold-induzierter systemischer Lupus erythematodes. [Gold-induced systemic lupus erythematosus.] Monatsschr Kinderheilkd 1988 136(9) 644-6. 

Hoigne R, Biedermann HP, Naegeli HR. INH-induzierter systemischer Lupus Erythematodes 2 Beobachtungen mit Reexposition. Schweiz Med Wochenschr 1975 105(50) 1726. 

Desikan KV, Ramanujam K, Ramu G, Balakrishnan S (1975) Autopsy findings in a case of lepromatous leprosy treated with clofazimine. Lepr Rev 46 117 Djawari D (1978) Zur Problematik des medikamentos-induzierten Lupus erythematodes. Z Hautkr 53 180... 

Isenberg JI, Goldstein H, Korn AR, Ozeran RS, Rosen V (1968) Pulmonary vasculitis - an uncommon complication of ulcerative colitis. N Engl J Med 279 1376-1377 Jaup H (1978) Salazosulfapyridin-induziertes Lupus-erythematodes-Syndrom bei Colitis ulcerosa. Dtsch Med Wochenschr 103 1211-1213 Kandil E (1969) Fixed drug eruptions. Dermatologica 139 37... 

Millard LG, Rowell NR (1978) Chilblain lupus erythematodes (Hutchinson). A clinical and laboratory study of 17 patients. Br J Dermatol 98 497-506... 

Hatron PY, Plouvier B, Francois M (1982) Assoziation von systemischem Lupus erythematodes und Silikose. Kasuistik (5 Pat.). Rev Med Intern 3 245-246 Haustein UF (1998) Silica-induced Lupus erythematosus. Acta Derm Venereol 78 73-74... 

Haustein UF, Albrecht M (1996) Berufsbedingte progressive Sklerodermie, Pseudosklerodermie und systemischer Lupus erythematodes. Derm Beruf Umwelt 44 77-80 Haustein UF, Herrmann K (1994) Environmental scleroderma. Clin Dermatol 12 467-473... 

Mehlhorn J, Gerlach C (1990) Gemeinsames Auftreten von Silikose und Lupus erythematodes. Z Erkr Atmungsorgane 175 38-41... 

Pseudo-Lupus-erythematodes-Syndrome dutch ein Venenmittel. Internist. Prax., IS, 789. 

Use of this drug in other flelds, including chronic hepatopathy, in which it is claimed to improve hepatic function, has been reported. When employing it for this purpose, Dohrmann et al. (29 ) found that flush reactions or skin allergy occurred in some 2% of cases. Szabolcsi in Hungary has described a patient with discoid lupus erythematodes in whom a severe toxicoderma developed after 4 weeks of treatment with xanthinol nico-... 

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