LUDI program

K calc = 0.50 xM, K exp = 3.6 xM). Larger differences between the predicted and measured inhibition constants were obtained for weak LAP inhibitors (10-12, K exp > 100 xM), which structures were not found by the LUDI program.73... 

In another study reported by a group from Agouron Pharmaceuticals, the LUDI program was used to help design novel ligands for the protein FKBP-12, which plays an important role in signal transduction pathways. ... 

Bohm HJ. The computer program LUDI a new method for the de novo design of enzyme inhibitors. J Comput Aided Mol Design 1992 6 61-78. 

Figure 5.27 Design of an SP route to a focused SP library of phenyl stilbenes selected with the program LUDI for the Kvl.3 potassium channel.

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