Luciferase adenylate binding

Firefly Luciferase C-Terminal Domain in Luciferyl-Adenylate Binding... 

IMPORTANCE OF FIREFLY LUCIFERASE C-TERMINAL DOMAIN IN BINDING OF LUCIFERYL-ADENYLATE... 

Provisional understanding of the catalytic mechanism can be deduced by comparison with other ATP-binding enzymes from both prokaryotes and eukaryotes, such as peptide synthetases, luciferases, and acetyl-CoA and acyl-CoA synthetases. These enzymes either form an adenylate intermediate, which is further esterified with CoA as for 4CLs (e.g., acetyl-CoA synthetases (Acs), and acyl-CoA synthetases), or are oxidized by molecular oxygen (luciferases), or are enzyme-bound CoA derivatives, such as 4 -phosphopantheteine (nonribosomal peptide synthetases). 

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