Omeprazole Lorazepam

Gait disturbances (attributed to benzodiazepine toxicity) occurred in two patients given triazoiam and lorazepam or flu-razepam with omeprazoie, and another patient taking diazepam and omeprazole became wobbly and sedated. Lansoprazole, pan-toprazole, or rabeprazole appear not to interact to a clinically relevant extent with diazepam. Diazepam serum levels are increased by esomeprazole but the clinical relevance of this is unknown. 

Two elderly patients, both smokers, taking triazolam with lorazepam or flurazepam, developed gait disturbances when they were given omeprazole 20 mg daily. They rapidly recovered when eitherthe benzodiazepines or the omeprazole were stopped. A brief report deseribes a patient taking omeprazole who became wobbly and sedated by small, unspeeified doses of diazepam, and another report describes a patient who developed toxie levels of nordiazepam and remained unconscious for 13 days after reeeiv-ing a high dose of clorazepate (1500 mg over about 29 hours) and omeprazole 80 mg daily. ... 

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