Long acting phenothiazines

Short-acting phenothiazine drugs are used commonly in equine practice for sedation and restraint (see Ch. 15), while long-acting phenothiazines are used in human patients as antipyschotic agents. 

Fluphenazine A phenothiazine neuroleptic that is often formulated as a long-acting decanoate. 

WARNING Long-acting p2-agonists may t risk of asthma-related death Uses COPD maint Action LA p2-agonist, relaxes airway smooth muscles Dose 15 meg neb bid, 30 meg/d max Caution [C, ] w/ CV Dz, X Contra Not for acute asthma component hyp sensitivity peds w/ phenothiazines Disp Meg neb SE Chest/back pain, D, sinusitis, leg cramps, dyspnea, rash, flu-synd, t BP, arrhythmias, heart block J-K EMS Monitor ECG for arrhythmias, heart block, and hypokalemia (flattened T waves) t risk of acute asthma attack, treat w/ shortacting p-agonist OD May cause CP, palpitations, muscle tremors and cramps, and syncope symptomatic and supportive... 

Chlorpromazine is well absorbed mainly from the jejunum. It is extensively metabolized in the liver, which produces several active metabolites. When given intramuscularly, the phenothiazine neuroleptics avoid metabolic degradation (first-pass metabolism), making them more beneficial as long-acting depot antipsychotics (see Table 2). 

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