Logic-centred methodology

In summary, had the "logic-centred methodology" been used, a "synthesis tree" such as the one shown in Diagram 3.2 would have resulted and the different alternative synthetic sequences generated would have been evaluated. 

In the particular case of natural products, once all the possibilities that the "logic-centred methodology" offers have been explored, it is pertinent to consider the biogenetic pathways by which they are synthesised in Nature since these can be a source of inspiration and may introduce an intrinsic element of elegance into the synthetic plans. In this context, tropine (131 offers a unique example in the history of organic synthesis. In 1902 this rather simple alkaloid was synthesised by Willstatter from cycloheptanone [8] through a sequence of about twenty steps, as shown in Scheme 3.4. 

In connection with the "logic-centred methodology" we have referred to the elaboration of a "synthesis tree" by a process that involves the stepwise generation... 

Logic-centred synthetic analysis methodology Summary 1) Structural synthetic analysis of the target molecule ... 

Logic-centred synthetic analysis methodology Summary.329... 

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