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LMW-PEI

Aigner A, Fischer D, Merdan T, Bms C, Kissel T, Czubayko F (2002) Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression. Gene Ther 9 1700-1707... [Pg.19]

Biodegradable PEI Derivatives Synthesized from LMW PEI Core Units... [Pg.153]

Biodegradable PEI-PEG-copolymers [122] were synthesized derived from LMW PEI (0.6, 1.2, or 1.8 kDa) and hydrophiUc bifunctional 2 kDa PEG-di (succinimidyl succinate). Copolymers containing succinate ester linkages were degradable under physiological conditions and non-toxic. In vitro transfection efficiency of the synthesized copolymer increased up to three times higher than that of the native LMW PEL... [Pg.153]

Poly(ethylenimine-co-L-lactamide-co-succinamide) was synthesized as a copolymer of 1.2 kDa LMW-PEI and 1 kDa oligo(L-lactic acid-co-succinic acid) [ 123]. The resulting copolymer P(El-co-LSA) (8 kDa) forms small poly-plexes (ISOnm) with a positive surface charge of + 18 mV. Similar to LMW PEI, the copolymer exhibited a low toxicity profile P(EI-co-LSA) degrades via base-catalyzed hydrolytic cleavage which is higher at pH 7 than at pH 5. [Pg.154]

See other pages where LMW-PEI is mentioned: [Pg.341]    [Pg.106]    [Pg.107]    [Pg.236]    [Pg.420]    [Pg.421]    [Pg.242]    [Pg.245]    [Pg.515]    [Pg.515]    [Pg.522]    [Pg.145]    [Pg.149]    [Pg.154]    [Pg.157]    [Pg.157]    [Pg.157]    [Pg.158]    [Pg.341]    [Pg.106]    [Pg.107]    [Pg.236]    [Pg.420]    [Pg.421]    [Pg.242]    [Pg.245]    [Pg.515]    [Pg.515]    [Pg.522]    [Pg.145]    [Pg.149]    [Pg.154]    [Pg.157]    [Pg.157]    [Pg.157]    [Pg.158]    [Pg.235]    [Pg.225]    [Pg.435]    [Pg.33]    [Pg.33]    [Pg.150]   
See also in sourсe #XX -- [ Pg.106 ]



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