Liver collapse fibrosis

Liver collapse fibrosis must be differentiated from proper liver fibrosis, which displays increased deposition of a qualitatively altered extracellular matrix. It results from a collapse of the reticular fibres following liver cell necrosis. A primary collapse arises subsequent to confluent cell-group necrosis in a previously normal parenchyma. A secondary collapse develops as a result of extensive necrosis in previously damaged parenchyma (e.g. cirrhosis). 

Fig. 21.14 Periportal and septal fibrosis following severe acute viral hepatitis B liver architecture clearly disrupted older collapse fields with condensed reticular fibres (Gomori s reticulin stain)...

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