Lithium diisopropylamidc

The possibility of preparing /3-amino acids in a similar way to the a-amino acids (vide supra) has been explored14. Thus, the six-membered, racemic tetrahydro-4(3//)-pyrimidinone 1 forms the enolatc with lithium diisopropylamidc at —78 CC. Subsequent alkylation with a number of halides gives excellent diastereoselectivities in favor of the trara-isomer 2. 

BuiylMHlitim-TeirametbylethyJenc dUmine. 59 Lithium hydride, 165 Potassium r-butoxide, 112 Pouuuum diisopropylamidc, 255 PotosMum hcxamcihyldoilaiide, 257 Potasuum hydrkk 257 MmioxYiAitON... 

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