Nifedipine Lisinopril

Cardiovascular Acetyldigosin, ajmaline, amiodarone, aprindine, bepridil, bezaflbrate, captopril, dinepazide, clopidogrel, coumarins, diazoxide, digoxin, dipyridamole, disopyramide, doxazosin, enalapril, flurbiprofen, fur-oxemide, hydralazine, lisinopril methyldopa, metolazone, nifedipine, phenindione, procainamide, propanolol, propafenone, quinidine, ramapril, spironolactone, thiazide diuretics, ticlopidine, vesnarinone... 

Compliance. Multidrug therapy poses a substantial problem of compliance. Since treatment will be lifelong it is well worthwhile taking the trouble to find the most convenient regimen for each individual. A single daily dose would be ideal and to achieve this sustained-release formulations and fixed-dose combinations are used. Examples include Tenoretic (atenolol + chlortalidone), Tenif (atenolol + nifedipine) and Zestoretic (lisinopril + hydrochlorothiazide). 

Asberg A, Karsten M, Vassbotn, Elartmann A. Better microvascular function on long-term treatment with lisinopril than nifedipine in renal transplant recipients. Nephrol Dial Transplant 2001 16 1465-1470. 

No evidence of either a pharmacokinetic or adverse pharmacodynamic interaction was seen in 12 healthy subjects given single doses of nifedipine retard 20 mg and lisinopril 20 mg the effects on blood pressttre were additive. Similarly, there was no pharmacokinetic interaction between single doses of slow-release nifedipine 20 mg and benazepril 10 mg in healthy subjects the effects on blood pressure were additive and the tach-ycardic effect of nifedipine was attenuated by benazepril. The manufacturer of fosinopril notes that the bioavailability of fosinoprilat, the active metabolite, was not altered by nifedipine. - Similarly, the manufacturer of moexipril notes that no clinically important pharmacokinetic interaction occurred with nifedipine in healthy subjects. ... 

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