Lisinopril aldosterone

In patients with severe CHF whose renal function may depend on the activity of the renin-angiotensin-aldosterone system, treatment with ACEIs may be associated with oliguria or progressive azotemia and, rarely, with acute renal failure or death. Impaired renal function decreases lisinopril elimination. The elimination half-life of quinaprilat increases as Ccr decreases. Dosage adjustment may be necessary for quinapril, benazepril, ramipril, and lisinopril. Impaired renal function decreases... 

Captopril is designated chemically as l-[(2S)-3-mercapto-2-methylpropionyl]-L-proline (14) (Fig. 8). It is used as an antihypertensive agent through suppression of the renin-angiotensin-aldosterone system [36,37], Captopril and other compounds such as enalapril and lisinopril prevent the conversion of angiotensin I to angiotensin II by inhibition of ACE. 

Lisinopril (Prinivil, Zestril) 10-40 1 receiving potassium-sparing diuretics, aldosterone... 

Lisinopril is an angiotensin I-converting enzyme (ACE) inhibitor. It competitively inhibits ACE, prevents angiotensin I conversion to angiotensin II, and is a potent vasoconstrictor that also stimnlates aldosterone secretion. Results are a decrease in sodinm and fluid retention, a decrease in BP, and increase in dinresis. It is indicated in the treatment of hypertension treatment of heart failure not responding to dinretics and digitalis and treatment of acute MI within 24 honrs in hemodynamically stable patients. 

ACE inhibitors (e.g., captopril, enalapril, lisinopril, etc.) compete with angiotensin I for binding of ACE, thus reducing the formation of angiotensin II. This results in decreased vasoconstriction. Secretion of aldosterone is also reduced, resulting in decreased fluid volume, and vasodilatation is promoted through an inhibition of the metabolism of bradykinin, a potent vasodilator. This produces a net vasodilatation, accompanied by a decrease in plasma volume, resulting in a fall in blood pressure. 

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