Lipoxygenase reactive species produced

Figure 13.5. Pathways for the oxidative modification of low density lipoprotein. The lipoxygenase pathway produces hydroperoxides that catalyse the oxidation of LDL. The active oxygen pathway involves the direct oxidation of LDL with reactive oxygen species such as superoxide. The oxidized fatty acids (FA-OOH) of phosphatidylcholine (PC) in LDL are preferentially hydrolysed by phospholipase A and decomposed into aldehydes that interact with ApoB of LDL, leading to the formation of foam cells via macrophage and scavenger receptors.

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