Liposomes solubilization sites

Therefore, micelle-forming surfactant molecules (e.g., SDS) will be present in three different forms, namely, on the lipid surface, as micelles, and as monomeric surfactant molecules in solution. Lecithin will form liposomes, which have also been detected in nanoemulsions for parenteral nutrition [77], Mixed micelles have to be considered in glycocholate/lecithin-stabilized and -related systems. Micelles, mixed micelles, and liposomes are known to solubilize drugs, and are therefore attractive alternative drug-incorporation sites (especially with respect to the low incorporation capacity of lipid crystals). 

In the case of water-insoluble solutes which do not modify bilayers, such as single-chain alcohol molecules, the solubilization process can be treated within the frame work of a solvent exchange model (40). A liposome molecule (L) has A ax potential sites for alcohol binding. These sites are occupied by water in a buffer solution, and therefore this model is based on the one-to-one exchange of water and solute in the membrane, as follows ... 

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