Liposomes corked

An additional possibility could be the transport of polymeric tensides, which are themselves not able to destroy the polymeric liposomes, to the membrane of the cancer cell. For the release of the incorporated tenside the membrane of the carrier liposome must contain destabilizable areas comparable to cork-stoppers (11). The destabilizable areas could eventually be opened by pTiotochemical destabilization of the membrane ( 73), variation of pH (74), increase of temperature ( 75), or enzymatic processes. 

In such phase-separated partially polymerized liposomes the corks consisting of cleavable lipids can be visualized by freeze-fracture electron microscopy101) and photobleaching 100). 

Fig. 6 Destabilization of labile domain in polymeric liposome leading to release of entrapped substance ("cork-model")...

It is reported by Okahata [80] that glycine-based 2Ci6-gly-NH3 bilayer-corked capsule membrane s permeability is pH responsive. This implies that the addition of HCl/NaOH causes a change in the molecular packing of 2Ci6-Gly-NH3+ in the bilayer. In DDS application, pH-sensitive liposomes, where dissociative bilayer-forming molecules are incorporated, would be useful for their clinical implications. They would release encapsulated drug when... 

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