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Liposomal gene delivery systems

Ruponen M, Yla-Herttuala S, Urtti A. Interactions of polymeric and liposomal gene delivery systems with extracellular glycosami-noglycans physicochemical and transfection studies. Biochim Biophys Acta 1999 1415 331-341. [Pg.682]

Ropert, C., Liposomes as a gene delivery system, Brazilian Journal of Medicine and Biology Research, 1999, 32, 163-169. [Pg.14]

Nonviral vector systems are usually either composed of a plasmid based expression cassette alone ( naked DNA), or are prepared with a synthetic amphipathic DNA-complexing agent (84, 88). Gene delivery systems based on nonviral vectors mainly comprise cationic liposomes, DNA-polymer-protein complexes, and mechanic administration of naked DNA. An idealized/optimized multifunctional nonviral gene delivery system is depicted in Figure 13.4. [Pg.345]

The use of HVJ liposome gene delivery for clinical trials has been evaluated in several animal models, and we believe that this gene delivery system is promising for the treatment of cancers, chronic diseases, and organ transplantation [19]. [Pg.262]

Non-viral gene delivery systems 9.2.1. DNA/DNA liposome complexes... [Pg.232]

To develop an efficient gene delivery system, it seems necessary to understand the extra- and intracellular processes involved in the overall transfection mechanism. This will lead to understanding the mechanism, which is necessary for developing novel lipid-based non-viral vectors. For this purpose, cationic liposomes and pDNA are used widely to understand the cellular mechanism involved in the transfection (Fig. 13.3). [Pg.659]

Currently, transport of exogenous DNA to cells can be achieved using viral and nonviral vectors or as naked DNA. The simplest nonviral gene delivery system simply uses naked DNA. The overall level of expression is much lower with naked DNA than with either viral or liposomal vectors. Naked DNA is also unsuitable for systemic administration due to the presence of serum nucleases. [Pg.357]

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Gene delivery

Gene delivery systems

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