Lipoproteins aggregation

FIGURE 24.3 (a) A duct at the junction of the pancreas and duodenum secretes pancreatic juice into the duodenum, the first portion of the small intestine, (b) Hydrolysis of triacylglycerols by pancreatic and intestinal lipases. Pancreatic lipases cleave fatty acids at the C-1 and C-3 positions. Resulting monoacylglycerols with fatty acids at C-2 are hydrolyzed by intestinal lipases. Fatty acids and monoacylglycerols are absorbed through the intestinal wall and assembled into lipoprotein aggregates termed chylomicrons (discussed in Chapter 25). 

Chylomicrons are plasma lipoproteins (aggregates of protein and triglycerides) that carry dietary triglycerides from the intestine to all tissues via the bloodstream. 

Guarino, A.J., Tulenko, T.N., and Wrenn, S.P., Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size biological significance, Chem Phys Lipids, 142 (2006) 33 2. 

Involve on lipoprotein aggregation SMase-induced LDL aggregation... 

Chylomicrons are lipoprotein aggregates found in the lymph and the bloodstream. 

Fatty acids, glycerol, and monoglycerides that result from lipid digestion are absorbed into the lymph, recombined into triglycerides, and deposited into the bloodstream as lipoprotein aggregates. 

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