Lipophilicity Measurements by Capillary Electrophoresis CE

CE was early identified as a powerful experimental technique to monitor the partitioning of neutral solutes and the neutral form of ionizable compounds [67]. In the search of partitioning parameters closer than log Poa to the pharmacokinetic behavior of dmg compounds [68] several different CE experimental conditions were explored and recently reviewed in detail [5, 69]. 

Lipophilicity determination by CE exhibits the same advantages as all chromatographic methods, i.e. insensitivity to impurities, fast analysis time, low cost and 

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