Lipolysis, ACTH-induced

HT1 -R ligand ( 10) (a 1A-R, a2A-R, Dl-R, Hl-R, O-R) [inhibits Epinephrine-induced adipocyte lipolysis, increases ACTH-induced adipocyte lipolysis]... 

Cyclic AMP may also mediate the lipolytic effect of various hormones.99 Numerous lipolytic hormones (ACTH, glucagon, catecdiolamlnes, TSH, and others) Increase tissue levels of cyclic AMP by activation of adenyl cyclase.3-00 This effect Is potentiated by caffeine, an inhibitor of phosphodiesterase.3-80 Insulin, which lowers cyclic AMP levels also inhibits epinephrine induced lipolysis.301,102 Nicotinic acid, another lipolysls inhibitor, virtually obliterates the effects of epinephrine on cyclic AMP levels in isolated fat cells.303 xhe fact that exogenous cyclic A stimulates lipolysls in isolated fat cells301 adds further credence to the hypothesis that hormone induced lipolysls may be mediated by this nucleotide. 

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