Lipids spatial shape

The solid-state structure of neutral FQ is stabilized by a strong intramolecular hydrogen bond (d = 2.173 A) between the anilino N(ll) and the tertiary amino N(24) (see Chap. 3.1, [128]). When in solution with a low dielectric constant (chloroform, k = 5.5) such as the lipid environment, NMR data show that the spatial structure of FQ is much the same as in the crystal [159]. This peculiar shape leads to an increase of its hydrophobicity and results in the rejection of the bulky ferrocenyl moiety toward the outside [157]. 

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