Lipid monocationic

The structure of a cationic lipid can be broken-down into three structural elements a lipophilic lipid anchor comprising one or—mostly—two long alkyl chains or Choi, a spacer, and a polar, positively charged head group consisting of one or more quaternised or protonatable amino groups. Figure 2 shows a few of the well-known, older cationic lipids, which can be classified as either monocationic or polycationic lipids. A series of recently synthesized cationic lipids will be discussed later. 

Fichert T, Regelin A, Massing U. Synthesis and transfection properties of novel non-toxic monocationic lipids. Variation of lipid anchor, spacer and head group structure. Bioorg Med Chem Lett 2000 10(8) 787-791. 

A combinatorial library of aminoglycerol-based monocationic lipids synthesised using a linear solid-phase approach was recently described by Yingyongnarongkul [159] (see Fig. 14). 

Lipofectamine ) Monocationic lipid Mice 2 d 24 pmol of siRNA mesencephalon Lateral brain ventricle 59... 

---