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Linopirdine cognition enhancer

Linopirdine (175) has been assayed in a wide range of animal models for cognitive enhancement. In mice, linopirdine enhanced perfor-... [Pg.819]

Phase I clinical studies with DMP 543 (181), up to a single dose of 55 mg, demonstrated that it was well tolerated and had an improved mean elimination half-life of 30-57 h (linopirdine was 0.4-3.2 h) (549). To date, preclinical studies describing cognitive enhancement with these compounds have not been published. The development of DMP 543, after reaching phase II clinical trials as a potential therapy for the treatment of Alzheimer s disease, has now been discontinued (DuPont Pharm, 2000 Annual Report). [Pg.820]

See other pages where Linopirdine cognition enhancer is mentioned: [Pg.996]    [Pg.997]    [Pg.42]    [Pg.520]    [Pg.996]    [Pg.997]    [Pg.166]    [Pg.818]   
See also in sourсe #XX -- [ Pg.6 , Pg.818 , Pg.819 ]



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