Linkers succinoyl

A soluble aminomethylated polyethylene glycol and a succinoyl linker were used to support a 9-fluorenylmethyl group for solution-phase glycosylation by the sulfoxide method. With the help of temporary protection by a 6-O-triphenylmethyl ether, the method could be carried out iteratively to form disaccharides (Scheme 4.69) [379],... 

Scheme 9.5 Attachment of the succinoyl linker (a) in one step as polymer-supported hemiester (b) in a two-step sequence (a) attaching to the acceptor succinoyl (using succinyl anhydride) first, followed by (b) the attachment of MPEG-OH to the free carboxyl of the succinoyl formed in step a.

An elegant universal linker was designed by Lyttle et al. [117]. A l-0-(4,4 -dimethoxytrityl)-2-0-succinoyl-3iV-allyloxycarbo propane linker is... 

To synthesize an oligosaccharide, MPEG is bound to a hydroxyl of the first monosaccharide through the succinoyl diester linker (Scheme 1). Next, another hydroxyl of this monosaccharide is deprotected, glycosylated, temporary protection on the second monosaccharide is removed and the above process is repeated until the required oligosaccharide is synthesized. Although incomplete glycosylation can... 

TentaGel-N, linked via the succinoyl linker to a monosaccharide acceptor was utilized using trichloroacetimidate chemistry to prepare disaccharides [34] and trisaccharides [78]. It was observed that TentaGel is slightly unstable under the acidic conditions required by trichloroacetimidate chemistry [78], most likely due to the acid sensitivity of PEG [79]. No similar sensitivity was observed in similar applications employing Argogel [78]. 

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