Linkers reagents

Fig. 4. Frequently used photoactivatable bifunctional cross-linker reagents...

Novel Polymer and Linker Reagents for the Preparation of Protease-inhibitor Libraries... 

An oligonucleotide with a 5 -ferrocene moiety and a 3 -thiol group has been prepared using the ferrocene linker reagent (214) in the last round of oligonucleotide synthesis. The oligonucleotide was used to prepare a redox-active monolayer on gold. 

Scheme 1.7 Synthesis of natural product-like molecules with unprecedented scaffold diversity. Initially, building blocks were added iteratively to a fluorous-tagged linker, with intermediates purified by fluorous-solid phase extraction. Metathesis cascades were used to reprogramme the scaffolds and to release final products from the fluorous-tagged linker. Reagents and conditions. (1) Grubbs first-generation catalyst, 21a 23% 21b 56% (2) fluorous-tagged Hoveyda-Grubbs second-generation eatalyst, 21c 33%.

Weik S, Rademann J (2003) A phosphorane as supported acylanion equivalent linker reagents for smooth and Versatile C-C coupling reactions. Angew Chem Int Ed 42 2491-2494... 

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