Linkers crosslinked polystyrene resin

Scheme 7.13. Solid-phase synthesis with Pam linker on polystyrene resin. Note that polystyrene resin is crosslinked by incorporating a small quantity of divinylbenzene.

Aminomethylated, crosslinked polystyrenes constitute very valuable and versatile resins for a variety of applications. The amino group can be easily acylated for the introduction of spacer and linker molecules and it was also used for the synthesis of polymer-bound carbodiimides. - In Scheme 1 S.4.4, some of the most common synthetic accesses to aminomethylated polystyrenes are summarised. 

Appropriate allylic linker systems can be obtained with a three-step synthetic procedure starting from polystyrene. Selective Uthiation of polystyrene 604 (1%DVB crosslinked) was achieved by addition of Buli in combination with TMEDA and subsequent conversion with allyldimethylsilyl chloride gave resin 666 with an average siUcon content of 1.3 mmol/g. Diversity could... 

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