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Linear Systems of Binding Sites

In this section we omit the second level and extend the model of Section 7.1 to a system of m linearly arranged subunits each of which has a one-binding site. In order to focus on the origin of cooperativity in such a system, we assume that the direct interaction between ligands is negligible. Hence any correlation between ligands is necessarily indirect. This model is essentially the same as that discussed in Sections 4.7, 5.6, and 6.3, but now the number of subunits m is not fixed. [Pg.242]

For any finite m, it is more convenient to work with the closed cyclic systems. We have seen that a linear open system of four identical subunits has two different intrinsic binding constants = 16 ). Thus, in general, the sites are not... [Pg.245]

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Linear systems

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