Lindane endocrine disruption

Fig. 9. Relationship between the steady-state bioconcentration factors on a lipid basis (BCFl) of chemicals in different fish species and the n-octanol/water partition coefficient (Kqw) (log/log scale). ( ) Solid circles are chemicals with known endocrine-disrupting properties. Abbreviations of the chemicals p,p -DDT 2,2-bis-(p-chlorophenyl)-l,l,l-trichloroethane. OCDD octachlorodibenzo-p-dioxin. TCDD tetrachlorodibenzo-p-dioxin. HCB hexachloro-benzene. PCA pentachloroanisole. PeCB pentachlorobenzene. MX musk xylene. TeCB tetrachlorobenzene. NP nonylphenol. TCB tetrachlorobenzene. y-HCH y-hexachlorocyclo-hexane (Lindane). PCP pentachlorophenol. DCB dichlorobenzene. BPA bisphenol-A. PCBs polychlorinated biphenyls...

Symptomatology is essentially the same as that described for organochlorine insecticides. In many cases, convulsions are the first sign of toxicity without the progression of nerve hyperactivity seen in other classes of organochlorine insecticides. More recently, evidence of endocrine disruption in both mammalian and other species has been accumulating for several cyclodiene pesticides including chlordane, aldrin, dieldrin, lindane, and endosulfan. 

It is also clear that it is difficult to relate cause and effect to any specific chemical since, with the exception of point source effluents, many waterways contain a multitude of chemicals, of which the active endocrine disruptor may not be that which has been measured in the water or tissue. For such reasons, many studies have used in vitro experiments in which isolated tissue, either from a control animal or one captured in a polluted water system, is exposed to a single pollutant in the laboratory. Such experiments have shown significant disruption to testicular activity by a wide range of xenobiotics, including cadmium, lindane, DDT, cythion, hexadrin and PCBs. ... 

---