Lincos amine

The Grignard reagent from (l-chloroethyl)dimethylphenylsilane, prepared in turn by a-methylation of (chloromethyl)dimethylphenylsilane, acts as a hydroxyethylating reagent after oxidative cleavage its use can be seen in a stereoselective synthesis124 of lincos-amine, the sugar component of the antibiotic lincomycin. 

---