Linaria saxatilis var.glutinosa

E-isolinaridial and E-isolinaridial methylketone are two neo-clerodane diterpenoids isolated from the aerial parts of Linaria saxatilis var. glutinosa (Schrophulariaceae). Benrezzouk et al. evaluated these compounds on multiple inflammation pathways and found that they were not COX-1/COX-2 inhibitors [139]. However, E-isolinaridial and E-isolinaridial methylketone were dual inhibitors against purified phospholipase A2 and 5-lipoxygenase. E-isolinaridial and E-isolinaridial methylketone showed potent inhibition of cell-free 5-LOX enzyme with IC50 values of 0.42 pM and 1.41 pM,... 

Fig. (19). Neo-clerodane diterpenes from Linaria saxatilis var. glutinosa.

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See also in sourсe #XX -- [ , ]

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